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By Denham M.C., Whittaker J.

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Extra info for A Bayesian approach to disease gene location using allelic association (2003)(en)(11s)

Sample text

Lamellenknochen (Haverssche Osteone im Polarisationslicht); Phasenkontrastaufnahme, 40´ Abb. 30. Geflechtknochen im Polarisationslicht; HE, 30´ 22 2 Normale Anatomie und Histologie Auch pathologische Prozesse in der Kortikalis fçhren im Ræntgenbild zu einem Defekt der normalen Knochenstruktur. Bei sich primår im Markraum abspielenden Låsionen (z. B. Osteomyelitis, Knochentumor) ist ræntgenologisch vor allem die endosteale Knochenschicht zu beachten, die normalerweise scharf konturiert sein muû.

An den Enden der Knochen versorgen die Aa. accessoriae (2) die Epi- und Metaphysen mit Blut; sie anastomosieren mit den diaphysåren Kapillaren und zweigen terminale Øste zum Knochenmark, zur Kortikalis und Spongiosa sowie zum Gelenkknorpel (3) ab. Das Knochenmark wird von einem unterschiedlich feinen Netz von Arterien durchzogen. Wåhrend der Wachstumsperiode wird die Epiphyse separat blutversorgt. Offenbar erfolgt die Blutversorgung der åuûeren Kortikalisschicht auch durch die reichlich vorhandenen periostalen Blutgefåûe (4), die mit den kortikalen Kapillaren in Verbindung stehen.

In der histologischen Abb. 37 sieht man mehrere groûe Osteoklasten (1), die mehrere blåschenfærmige Kerne besitzen. Ein Osteoklast liegt in einer tiefen Howshipschen Lakune (2), wo verkalkte Knochensubstanz herausgelæst wurde. Dadurch werden die Knochentrabekeln wellig begrenzt. Der schnellen Vermehrung und hohen Aktivitåt dieser Zellen auf bestimmte Reize hin steht ihre begrenzte Lebenszeit gegençber. Nach beendeter Resorption bleibt eine leere Lakune zurçck, die histologisch eine abgelaufene Knochenresorption anzeigt.

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