By Julie A. Ross, Kimberly J. Johnson, Logan G. Spector, John H. Kersey (auth.), Gregory H. Reaman, Franklin O. Smith (eds.)
This publication is a finished and updated compendium on all facets of early life acute lymphoblastic and acute myeloid leukemia, which jointly represent the main widespread melanoma within the pediatric age team. After introductory chapters at the epidemiology and biology of pediatric leukemia, remedy issues are commonly reviewed, with emphasis at the use of risk-adjusted therapy methods. Promising distinctive brokers are mentioned, and techniques for the improvement of latest brokers are appraised. The overdue results of leukemia and its remedy are then thought of intensive, with due awareness to administration of the psychosocial effect of the disorder. eventually, worldwide innovations to enhance leukemia care and end result are reviewed, and destiny instructions mentioned. The authors are across the world famous specialists and provide a mostly evidence-based consensus on etiology, biology, and therapy. This guide has far-reaching applicability to the medical analysis and administration of pediatric leukemia and should turn out priceless to experts, generalists, and trainees alike.
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Additional resources for Childhood Leukemia: A Practical Handbook
57 References............................................................................... L. org M. edu A. Biondi Universita Milano, Ospedale San Geraldo, Monza C. edu Discoveries of the underlying biological pathways that drive leukemogenesis in children have taken place at an astonishing pace. , transgenic and “knock out” models). More recently, advances in high-throughput genomics and progress in stem cell biology have transformed the field of cancer biology in general and perhaps more so in hematological malignancies.
5 Conclusion In conclusion, it will be important for epidemiologists, clinicians, basic scientists, geneticists, and other disciplines to work together to develop a comprehensive interdisciplinary study of childhood leukemia, which includes bidirectional sharing of information across disciplines. 9. The COG CCRN would be used for the usual case-control study approach. For childhood leukemia, focus would be centered on exposures that are mainly important during the in utero/neonatal period, including high birth weight, vitamin supplements, infections, and chemicals.
Paediatr Perinat Epidemiol 21(4):293–299 Michel G, von der Weid NX et al (2007) The Swiss Childhood Cancer Registry: rationale, organisation and results for the years 2001–2005. Swiss Med Wkly 137(35–36):502–509 Milne E, Laurvick CL et al (2007) Fetal growth and acute childhood leukemia: looking beyond birth weight. Am J Epidemiol 166(2):151–159 Molloy AM, Mills JL et al (2002) Maternal and fetal plasma homocysteine concentrations at birth: the influence of folate, vitamin B12, and the 5, 10-methylenetetrahydrofolate reductase 677C– >T variant.