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Additional resources for Myasthenia Gravis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
A third goal is to determine the pharmacological and electrophysiological properties of cloned human neuronal AChR subtypes. In addition to expression studies in Xenopus oocytes, this will involve development of a series of permanently transfected cell lines. This should define the functional properties of AChR subtypes, which are the target of nicotine and potential subtype-specific nicotinic drugs now being developed. A fourth 28 Myasthenia Gravis goal is to determine the mechanisms by which chronic exposure to nicotine alters the amounts and functional properties of cloned human neuronal AChRs.
Author(s): Sanders DB, Tucker-Lipscomb B, Massey JM. Source: Annals of the New York Academy of Sciences. 2003 September; 998: 440-4. cmd=Retrieve&db=PubMed&list_ uids=14592912&dopt=Abstract • Active management in patients with ocular manifestations of myasthenia gravis. Author(s): Bentley CR, Dawson E, Lee JP. Source: Eye (London, England). 2001 February; 15(Pt 1): 18-22. cmd=Retrieve&db=PubMed&list_ uids=11318287&dopt=Abstract • Adsorption column for myasthenia gravis treatment: Medisorba MG-50.
These experiments will provide information on both the mechanisms of induction of these important regulatory cells, which are critical to both regulation and suppression of autoimmune disease, as well as on their specific role(s) in suppressing CNS autoimmune disease. ; Medicine; Washington University Lindell and Skinker Blvd St. Louis, Mo 63130 Timing: Fiscal Year 2002; Project Start 01-SEP-2002; Project End 31-AUG-2004 Summary: (provided by applicant): Homeostatic mechanisms play an essential role in synaptic function.